منابع مشابه
ESCRTs breach the nuclear border
The endosomal sorting complexes required for transport (ESCRT) are best known for their role in sorting ubiquitylated membrane proteins into endosomes. The most ancient component of the ESCRT machinery is ESCRT-III, which is capable of oligomerizing into a helical filament that drives the invagination and scission of membranes aided by the AAA ATPase, Vps4, in several additional subcellular con...
متن کاملESCRTs
hypothesis-driven research. I still relish the time when, as a naïve Ph.D. student, I was unaware of fashion and the need to please top journals. This allowed me to follow compulsively one aim, which I had convinced myself to be worthwhile. Other pieces of advice are to keep career plans flexible enough to allow collaborators to influence one's research direction and to synergise with local exp...
متن کاملPiecing together the ESCRTs.
High-resolution structural analysis has characterized nearly all of the individual domains of ESCRT (endosomal sorting complex required for transport) subunits, all of the core structures of the soluble complexes and many of the interactions involving domains. Recent emphasis in structural studies has shifted towards efforts to integrate these structures into a larger-scale model. Molecular sim...
متن کاملESCRTs are everywhere.
The ESCRT proteins are an ancient system that buds membranes and severs membrane necks from their inner face. Three "classical" functions of the ESCRTs have dominated research into these proteins since their discovery in 2001: the biogenesis of multivesicular bodies in endolysosomal sorting; the budding of HIV-1 and other viruses from the plasma membrane of infected cells; and the membrane absc...
متن کاملNeuronal Functions of ESCRTs
The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRNA function, viral budding, and the autophagy pathway in many tissues, including the nervous system. Indeed, dysfunctional ESCRTs are associated with neurodeg...
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ژورنال
عنوان ژورنال: Nucleus
سال: 2015
ISSN: 1949-1034,1949-1042
DOI: 10.1080/19491034.2015.1035844